Living with knee arthritis doesn’t have to mean living in constant pain—or undergoing surgery. Millions of Americans are now turning to non-surgical treatments to manage osteoarthritis in knees effectively. From advanced regenerative medicine and physical therapy to FDA-approved injections, discover the best knee arthritis treatments available in the United States that don’t involve going under the knife.
Understanding Knee Arthritis and Its Impact
Knee arthritis, especially osteoarthritis of the knee, is a leading cause of chronic joint pain for over 40s in the U.S. It significantly impacts mobility and quality of life. The CDC reports that over 32.5 million American adults live with osteoarthritis, with the knee being a primary affected area. While surgery is often a last resort, many patients are actively looking for non-surgical knee arthritis treatments—and thankfully, there are more options than ever.
Top Non-Surgical Treatments for Knee Osteoarthritis in 2025
1. Viscosupplementation Injections (Hyaluronic Acid)
FDA-approved and widely used, hyaluronic acid injections act as a lubricant and shock absorber in the knee joint. Brands like Synvisc-One, Euflexxa, and Orthovisc are among the top choices recommended by orthopedic specialists across the U.S.
Who it’s for: Ideal for patients with mild to moderate arthritis.
Effectiveness: Can reduce pain and improve function for up to six months.
Covered by insurance: Most Medicare and private insurers cover it.
2. Platelet-Rich Plasma (PRP) Therapy
Regenerative medicine has gained traction in the last decade, especially PRP therapy, which uses your body’s natural growth factors to repair damaged tissues.
Clinics to watch: Regenexx, Emory Healthcare Regenerative Medicine, and Mayo Clinic offer cutting-edge PRP solutions.
Why it works: PRP can stimulate cartilage repair and reduce inflammation.
3. Physical Therapy and Neuromuscular Training
Targeted physical therapy plans—especially those focusing on strengthening the quadriceps, glutes, and hamstrings—can significantly reduce pressure on the knee joint. Many physical therapy providers in the U.S., like ATI Physical Therapy and BenchMark Rehab Partners, now offer programs designed specifically for knee osteoarthritis.
Complementary tech: Tools like therapeutic ultrasound and electrical stimulation may enhance results.
4. Weight Management and Anti-Inflammatory Diets
Excess weight is a major contributing factor to joint degeneration. Lifestyle changes, including anti-inflammatory diets rich in omega-3s and antioxidants, are considered essential components of long-term knee arthritis management.
Recommended tools: Programs like Noom, WeightWatchers, and consultations with registered dietitians help patients build sustainable routines.
5. Bracing and Orthotics
Custom knee braces and orthotic inserts can provide immediate structural support. Brands such as DonJoy, Össur, and Breg offer clinically tested braces tailored for osteoarthritis in knees.
Added benefit: May delay the need for more invasive treatments.
The Role of Imaging and Diagnostics
High-resolution MRI, X-ray, and ultrasound play a crucial role in creating a personalized non-surgical treatment plan. Clinics offering advanced diagnostics, such as HSS (Hospital for Special Surgery) in New York and Cleveland Clinic, provide targeted insight for optimal care strategies.
Emerging Therapies Worth Watching
Innovations like stem cell therapy, gene therapy, and radiofrequency ablation are rapidly gaining momentum. While some are still under clinical trials, forward-thinking patients are already exploring them through leading U.S. pain management centers like National Spine & Pain Centers and BioXcellerator.
Final Thoughts: Choosing the Right Knee Arthritis Treatment Without Surgery
With so many non-invasive treatment options available in 2025, managing osteoarthritis in knees no longer means suffering through daily pain or rushing into surgery. Whether you're exploring PRP therapy, viscosupplementation, or simply refining your physical therapy approach, the key is working with a qualified provider to develop a personalized care plan.
If you’re in the United States and seeking knee arthritis treatment without surgery, consult a board-certified orthopedic specialist or pain management doctor to explore what works best for your condition, budget, and long-term goals.