Chronic Rhinosinusitis Treatment for Nasal Polyps: Drops, Removal, and Biologics

What Are Nasal Polyps?

Nasal polyps are teardrop-shaped swellings on the lining of the nasal passages or sinus cavities. They are not cancer, but they can block airflow and trap mucus, leading to more drainage, pressure, and recurring infections. Polyps are often associated with chronic inflammation patterns, including allergies, asthma, aspirin-exacerbated respiratory disease (AERD), and sensitivity to irritants. Diagnosis is usually confirmed by an ENT with a nasal exam or endoscopy. Imaging (such as CT) may be used when symptoms are severe, when complications are suspected, or when planning surgery.

Chronic Rhinosinusitis and Nasal Polyps

Chronic rhinosinusitis (CRS) generally means symptoms lasting 12 weeks or longer—blockage, thick drainage, facial pressure, cough from drip, fatigue, and smell loss. When polyps are present (CRSwNP), the issue is both inflammatory and mechanical: tissue is irritated, and the growths narrow the passages. Effective Chronic Rhinosinusitis Treatment usually targets three goals: reduce inflammation, improve ventilation and drainage, and prevent flare-ups that restart the cycle. Because inflammation can smolder between flare-ups, maintenance matters even when you feel “okay.” For some people, addressing triggers (allergens, smoke, workplace irritants) and treating comorbid asthma or allergies can improve overall control.

The Role of Biologics in Nasal Polyps Treatment

Biologics are targeted medicines that quiet specific immune pathways commonly involved in type 2 inflammation. Unlike therapies that mainly treat local symptoms, biologics aim to reduce the inflammatory signaling that helps polyps persist or return. Different options target different parts of the pathway (for example IL-4/IL-13, IL-5, IgE, or upstream signals like TSLP). They are typically used as add-on maintenance therapy under specialist care, usually after optimized topical treatment and sometimes after prior surgery—especially when polyps recur quickly or steroid side effects are a concern. Most biologics are given as injections on a schedule set by your clinician (some can be self-administered). Response is often assessed over months, not days, using symptoms, smell changes, and endoscopy findings.

Types of Biologics for Nasal Polyps

A specialist may consider:

IL-4/IL-13 pathway blockers: often used when type 2 inflammation is prominent and smell loss is severe.

IL-5 pathway blockers: may fit patients where eosinophils appear to be a key driver and recurrence is frequent.

Anti-IgE therapy: can be considered when allergic disease strongly overlaps with symptoms.

Upstream pathway blockers: searches like Tezspire Nasal Polyps refer to tezepelumab (Tezspire), which targets TSLP; suitability depends on your clinical profile, comorbid asthma/allergies, prior treatments, and local availability and indications.

Benefits of Biologics

For the right person, biologics may:

reduce polyp size and nasal blockage over time

improve smell, sleep quality, and daily comfort

reduce severe flare-ups and the need for repeated steroid bursts

reduce the likelihood of needing repeat Nasal Polyp Removal

Where Drops Fit In: Sprays, Rinses, and “Nasal Polyps Drops”

Many people use Nasal Polyps Drops to describe topical steroid sprays, drops, or steroid-mixed rinses prescribed by a clinician. These therapies are foundational because they act locally and usually have fewer whole-body effects than repeated oral steroids. Saline irrigation helps clear mucus and irritants; topical steroids reduce swelling and may keep smaller polyps controlled. Technique matters: if you rinse, do it first, then apply the medication as directed, aiming the nozzle slightly outward (away from the septum). Try not to “sniff hard” right after spraying, since that can pull medicine into the throat instead of keeping it in the nasal lining. Also, be cautious with over-the-counter decongestant drops unless a clinician advises them, because overuse can trigger rebound congestion.

When Surgery Is Considered (Nasal Polyp Removal)

Nasal Polyp Removal, typically done with endoscopic sinus surgery, can open blocked areas, restore drainage, and help sprays and rinses reach deeper sinus spaces. Surgery may be recommended when polyps are large, infections are frequent, smell loss is significant, or anatomy limits medication delivery. However, surgery does not switch off the underlying inflammation, so recurrence is possible. Long-term maintenance after surgery—rinses plus topical steroids, and sometimes biologics—often improves durability of results. Post-op routines can include daily irrigations and follow-up visits for cleaning and monitoring while healing.

Who May Be a Candidate for Advanced Therapy?

Biologics are most often considered for moderate-to-severe CRSwNP that remains uncontrolled despite optimized topical therapy, and sometimes after prior surgery. Factors supporting escalation can include frequent recurrence, repeated need for oral steroids, major impact on sleep or work, and coexisting asthma or difficult allergies. Your clinician may use symptom scores, smell testing, bloodwork related to inflammation, and endoscopy findings to monitor progress and decide whether to continue, switch, or step down therapy.

Conclusion: A Long-Term Strategy

CRSwNP is usually managed best with a layered plan: consistent rinses and prescribed drops/sprays, trigger management, and timely escalation when control is poor. If you keep cycling between short relief and fast recurrence, an ENT or allergy specialist can confirm the diagnosis and help match the next step—optimized topical therapy, surgery, or a biologic—to your history and goals. Tracking simple outcomes (smell, sleep, flare-ups, and steroid use) can make follow-ups faster and more productive.